“[A]lcohol hits people harder in their 40s and 50s than it did during their 20s and 30s. The reasons for this include changes in body composition to brain sensitivity and liver functioning. Lifestyle factors are at play, too. And since people tend to take more medications—both prescription and over-the-counter—as they age, there are more chances for uncomfortable and even dangerous booze-drug mixing.” That’s one answer. The other answer is that everything hurts more as you age, because the simple act of survival guarantees a larger collection of sorrows, regrets and nagging voices in your head telling you the world would be a better place without you in it, plus oh my God you are just so tired all the time, and even the things that once brought you pleasure now offer only the briefest of joys before they usher you into the world of pain in which you will reside for the duration while you run out the clock. But sure, let’s go with “body composition.” It’s not like we’re getting thinner anyway, we might as well suffer on that account too.