Tuesday, July 23rd, 2013

If You Drink Wine, Don't Exercise

"Resveratrol has received widespread attention as a possible anti-aging compound and is now widely available as a dietary supplement; much has been made of its role in explaining the cardiovascular health benefits of red wine, and other foods. In a new study, researchers at The University of Copenhagen surprisingly discovered that eating a diet rich in antioxidants may actually counteract many of the health benefits of exercise, including reduced blood pressure and cholesterol."

5 Comments / Post A Comment

paultsmithjr (#245,886)

As a biomedical research scientist who spent two + years working in a lab that specifically dealt with developing mouse models to accurately study anti-aging compounds and modulations, I can tell you that the work completed on resveratrol finds its foundation in false premise and smoke and mirrors. A gentleman by the name of David Sinclair, well esteemed Harvard professor and well cited scientist, began working with a mouse model where he removed the target of resveratrol through either direct transgenic or chemical means, in a genetically homogenous model (think purebreed dog, cat, or horse – it has practically the same chromosome variations from each parent, giving it its phenotype). When he did this, fireworks shot off and the Angel's played horns from the heavens, he showed their lives were substantially extended. To expand on this work, Sinclair fed these mice resveratrol, and be it as it may, by god, the result repeated! Father Sinclair found the fountain of youth, and being a Harvard man, he knew he needed to run into the Boston financial district and hire the finest PR firm he could. This firm put forth many articles you may remember from ~2006, where everybody was in heat about how red wine would make you live longer, because it was rich in Sinclair's magic chemical Resveratrol. And the board members over at glaxosmithkline were among those most aroused – because we all know they're only the finest purveyors of red wine. Thus, without ever finding out if resveratrol worked on mice that had copies of chromosomes from different sources, sort of like, umm, the thing they're supposed to represent, called HUMANS, a seven hundred million dollar deal was struck between Sinclair's Resveratrol company and GSK. Only a few years later, it was found that resveratrol had no effect on ageing in mice that have genomes more representative of humans, and to date, the target of resveratrol, even with additional billions of research funding and development, has not produced a single efficacious product. In a nutshell, Sinclair's PR sav and business mind is unparalleled in the biomedical community – he acted swiftly and reaped great reward for it. But if one wants to speak to his integrity, they may want to converse with another, because I have zero respect for his contribution of SIRT1 as a relevant target for disease modulation, and the consistent misguided research and press it has produced.

SidAndFinancy (#4,328)

@paultsmithjr You're saying you worked at Disney? Cool!

SkinnyNerd (#224,784)

@paultsmithjr How do paragraphs affect aging?

Nellie Melba (#245,980)

@SkinnyNerd That's your response to his incredibly awesome and informative comment? You're an idiot.

@paultsmithjr – I thought that was fascinating. Thank you. I wonder how much a PR budget figures into the already astronomical costs of medical research.

La Cieca (#1,110)

I'll stick with Unobtainium, thanks.

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